Low Temperature Physics: 47, 214 (2021); https://doi.org/10.1063/10.0003521
On possible role of hydrogen peroxide molecules in ion beam therapy of cancer cells
Sergey N. Volkov
Laboratory of Biophysics of Macromolecules, Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine, Kyiv 03143, Ukraine
Received October 31, 2020, published online January 26, 2021
The possible role of molecular products of cell radiolysis, in particular, hydrogen peroxide molecules, in blocking DNA activity in cancer cells during irradiation with heavy ions is investigated. It is supposed that hydrogen peroxide molecules can form long-lived molecular complexes with DNA atomic groups and, thus, prevent the realization of genetic information in the biological cells. Using the quantum-mechanical approach based on density functional method and implicitly taking into account the aqueous medium, the competitive interactions of water and hydrogen peroxide molecules with DNA nucleic bases have been analyzed. Estimates of the characteristic lifetimes of complexes of water molecules and hydrogen peroxide with atomic groups of DNA allow showing the possibility to block the genetic activity of DNA by hydrogen peroxide in biological cells after their irradiation with ion beams. The effect of DNA blocking in cancer cells could be enhanced by a decrease in the cell temperature.
Key words: ion beam therapy, DNA blocking, hydrogen peroxide, computational studies.