Low Temperature Physics: 47, 233 (2021); https://doi.org/10.1063/10.0003524
Fizika Nizkikh Temperatur: Volume 47, Number 3 (March 2021), p. 254-263    ( to contents , go back )

New express method for melatonin determination in the human body

D. O. Harbuz1,2, A. P. Pospelov1, V. I. Belan2, V. A. Gudimenko2, V. L. Vakula2, L. V. Kamarchuk3, Y. V. Volkova3, and G. V. Kamarchuk2

1National Technical University “Kharkiv Polytechnic Institute”, Kharkiv 61002, Ukraine
E-mail: zeyxes@gmail.com

2B. Verkin Institute for Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine, Kharkiv 61103, Ukraine

3SI “Institute for Children and Adolescents Health Care” of the National Academy of Medical Sciences of Ukraine, Kharkiv 61153, Ukraine
pos Анотація:1606

Received November 11, 2020, published online January 26, 2021

Abstract

Original fundamental properties of Yanson point contacts allow their application to research and technology development at a wide range of surrounding conditions. At low temperature these nanoobjects can be used as a main instrument of Yanson point-contact spectroscopy. At room temperature they can serve as a sensitive element of advanced nanosensors with excellent performance. The most important advantage of point-contact sensors in investigating complex gas media is the spectral nature of the response signal. The discovery of the spectral capabilities of point-contact sensors in the analysis of complex gas media allows us to speak in terms of spectral multifunctionality of Yanson point contacts and the expansion of the possibilities of their spectral application from the spectroscopy of electron-phonon interaction at low temperatures to spectroscopy of gaseous media at room temperatures. Using the spectral response of point-contact sensors, in this work we propose a new non-invasive method for the determination of melatonin, one of the important hormones characterizing the state of the human body. A series of procedures was proposed to find melatonin concentration in the human body as function of the response of a point-contact sensor to the action of the exhaled breath. It has been shown that the proposed method is accurate enough to be used for medical purposes in real time. The results of the study suggest that the problem of noninvasive determination of melatonin concentration in the human body can be successfully solved by using breath tests based on Yanson point contacts.

Key words: Yanson point contact, breath profile, melatonin, quantum sensor, selective detection.

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